副研究员
学习经历
2011.09-2016.06，四川大学，生物化学与分子生物学，博士
2007.09-2011.06，西华大学，生物工程，学士
工作经历
2020.07-至今, 重庆大学附属肿瘤医院，肿瘤内科，副研究员
2017.01-2020.06, 陆军军医大学，第二附属医院肿瘤科，博士后
研究方向、教学课程
研究方向：长期从事肿瘤细胞及免疫、代谢相关研究的基础研究。近期主研表观遗传及蛋白修饰等对造血干细胞分化和肿瘤微环境中免疫细胞功能的影响相关基础研究。
教学课程: 生物化学、免疫学
成果：1.文章2.专利3.项目4.获奖
文章：(第一或通迅)
1. FcγRIIB potentiates differentiation of myeloid-derived suppressor cells to mediate tumor immunoescape. Wu, Lei; Xu, Yanquan; Zhao, Huakan; Zhou, Yu; Chen, Yu; Yang, Shuai; Lei, Juan; Zhang, Jiangang; Wang, Jingchun; Wu, Yongzhong; Li, Yongsheng. Theranostics, 2022, 12(2): 842-858.
2. Inflammation and tumor progression: signaling pathways and targeted intervention Zhao, Huakan; Wu, Lei; Yan, Guifang; Chen, Yu; Zhou, Mingyue; Wu, Yongzhong; Li, Yongsheng. 2021
3. Microbiota-derived SSL6 enhances the sensitivity of hepatocellular carcinoma to sorafenib by down-regulating glycolysis. Zhang X; Wu L; Xu Y; Yu H; Chen Y; Zhao H; Lei J; Zhou Y; Zhang J; Wang J; Peng J; Jiang L; Sheng H; Li Y. Cancer Letters, 2020, 481: 32-44
4. RIPK3 Orchestrates Fatty Acid Metabolism in Tumor-Associated Macrophages and Hepatocarcinogenesis. Wu L; Zhang X; Zheng L; Zhao H; Yan G; Zhang Q; Zhou Y; Lei J; Zhang J; Wang J; Xin R; Jiang L; Peng J; Chen Q; Lam SM; Shui G; Miao H; Li Y. Cancer Immunology Research, 2020, 8(5): 710-721.
5. RNase T2 in Inflammation and Cancer: Immunological and Biological Views. Wu L; Xu Y; Zhao H; Li Y. Frontiers in Immunology, 2020, 11: 0-1554.
6. Fibrinogen-like protein 2 controls sepsis catabasis by interacting with resolvin Dp5. Zhou Y; Lei J; Xie Q; Wu L; Jin S; Guo B; Wang X; Yan G; Zhang Q; Zhao H; Zhang J; Zhang X; Wang J; Gu J; Liu X; Ye D; Miao H; Serhan CN; Li Y. Science Advances, 2019, 5(11): 0-eaax0629.
7. Polygonatum odoratum lectin induces apoptosis and autophagy by regulation of microRNA-1290 and microRNA-15a-3p in human lung adenocarcinoma A549 cells. Wu, Lei; Liu, Tao; Xiao, Yan; Li, Xin; Zhu, Yanan; Zhao, Yan; Bao, Jinku; Wu, Chuanfang. Int J Biol Macromol, 2016, 85: 217-226.
8. Role of reactive oxygen species-mediated MAPK and NF-kappaB activation in polygonatum cyrtonema lectin-induced apoptosis and autophagy in human lung adenocarcinoma A549 cells. Liu, Tao; Wu, Lei; Wang, Di; Wang, Haiyang; Chen, Jinwu; Yang, Chunlan; Bao, Jinku; Wu, Chuanfang. J Biochem, 2016, 160(6): 315-324.
9. Network-based identification of key proteins involved in apoptosis and cell cycle regulation. Wu, L; Zhou, N; Sun, R; Chen, X D; Feng, S C; Zhang, B; Bao, J K. Cell Prolif, 2014, 47(4): 356-368.
10. Anti-tumor and anti-viral activities of Galanthus nivalis agglutinin (GNA)-related lectins. Wu, Lei; Bao, Jin-Ku. Glycoconj J, 2013, 30(3): 269-279.
项目:
1. RIPK3通过FoxO1-PDK2信号通路诱导TAMs向M1型极化的分子机制研究(81901624, 国自然青年项目), 2020-2022 (21万，主持)
2. 肿瘤来源的外泌体通过Sp1/Fgl2-FCGRIIB通路诱导MDSC免疫抑制功能的分子机制研究(2019XQN10, 陆军军医大学青年培育项目), 2020-2022 (20万，主持)
3. 肿瘤来源的GMCSF通过Sp1/Fgl2-FCGRIIB通路诱导MDSC免疫抑制功能的分子机制研究(cstc2021jcyj-msxmX0111,重庆市自然科学基金面上项目)，2021.10.01-2024.09.30，(10万，主持)
4. RIPK3在肿瘤相关巨噬细胞脂肪酸代谢重编程中的作用研究(2017M613344,中国博士后61批面上)，2017-2020 (5万，主持)
5. RIPK3在肿瘤相关巨噬细胞脂肪酸代谢重编程中的作用研究(重庆博士后特别资助), 2017-2020 (5万，主持)
参研：
1. 肠道微生物调控PGC1α重编程肿瘤相关巨噬细胞脂代谢在肝癌发生中的作用机制(81920108027，国自然国际地区合作), 2020-2024 (248万，参与)
