职位：
重庆大学附属中心医院.重庆市急救医疗中心 内分泌代谢科主任
学习经历：
2013.07-2016.06 重庆医科大学内分泌代谢病 博士
2014.11-2015.11 美国亚利桑那大学 访问学者
2006.09-2009.06 第三军医大学内分泌代谢病 硕士
工作经历：
2016.08-至今 重庆大学附属中心医院 内分泌科主任，主任医师、教授、博导
2017.12-2019.12 重庆大学附属中心医院 科教科副科长
2015.07-2016.08 西南医院副主任医师、副教授、硕导
2009.07-2014.11 西南医院主治医师、讲师
2022年当选“重庆英才.创新领军人才”
2022年国家留学基金委高级访问学者留学计划支持
2022年重庆市级糖尿病足专病诊疗中心负责人
2022年重庆市糖尿病足医学研究中心负责人
2021年当选“重庆市中青年医学高端人才工作室”
2016年当选重庆中青年医学高端人才
2016年 重庆市学术技术带头后备人选
2015年“医疗新技术海外引进创新计划”人才
研究方向:
内科学（增龄性内分泌代谢病），急危重症内分泌与代谢性疾病，糖尿病足发病机制和修复、代谢综合征和医用仪器设备研发和转化。
学术（社会）兼职：
北美华人糖尿病学会（CADA）资深会员
美国保肢协会（ALPS）会员
中华医学会内分泌专委会全国青年委员
中华医学会糖尿病分会基础医学与转化学组委员
中华医学会糖尿病分会糖尿病足与周围血管病学组委员
中华医学会组织修复与再生学分会肢体保全学组委员
重庆市中西医结合学会糖尿病专委会副主任委员
重庆市中西医结合学会络病专业委员会副主任委员
重庆市中西医结合学会脑心同治专业委员会副主任委员
重庆市医学会糖尿病学专业委员会并发症学组组长
重庆医学会内分泌专委会委员
重庆市青年联合会（医药卫生界别）委员
成果：1.文章2.专利3.项目4.著作5.获奖
(一）文章
以第一或通讯作者发表的英文论文：
1. Deng L, Y Chen, Deng W. Letter by Deng et al Regarding Article, “Risk of Macrovascular and Microvascular Disease in Diabetes Diagnosed Using Oral Glucose Tolerance Test With and Without Confirmation by Hemoglobin A1c: The Whitehall II Cohort Study”. Circulation 2022 Aug 25. Online ahead of print.
2. Tianyi Chen, Peiyang Song, Min He, Shunli Rui, Xiaodong Duan, Yu Ma, David G. Armstrong, Wuquan Deng. Sphingosine-1-phosphate Derived from PRP-Exos Promotes Angiogenesis in Diabetic Wound Healing via S1PR1/AKT/FN1 Signalling Pathway. Burns&Trauma. Online ahead of print.
3. Song P, Chen T, Rui S, Duan X, Deng B, Armstrong DG, Ma Y and Deng W. Canagliflozin promotes osteoblastic MC3T3-E1 differentiation via AMPK/RUNX2 and improves bone microarchitecture in type 2 diabetic mice. Front. Endocrinol. 2022;13:1081039.
4. Duan Z, Song P, Yang C, Deng L, Jiang Y, Deng F, Jiang X, Chen Y, Yang G, Ma Y and Deng W. The impact of hyperglycaemic crisis episodes on long-term outcomes for inpatients presenting with acute organ injury: A prospective, multicentre follow-up study. Front. Endocrinol. 2022;13:1057089.
5. Xinyan Li, Huimin Zhao, Ling Yu, Huayue Chen, Wuquan Deng, and Wu Deng. Feature Extraction Using Parameterized Multisynchrosqueezing Transform. IEEE sensors journal.2022(22):14263-14272.
6. Wu Deng, Lirong Zhang, Wu Deng, Huiling Chen, Huimin Zhao. Multi-strategy particle swarm and ant colony hybrid optimization for airport taxiway planning problem. Information Sciences. 2022(612):576-593.
7. Yingjie Song, Xing Cai,Wu Deng, Wuquan Deng. Dynamic hybrid mechanism-based differential evolution algorithm and its application. Expert Systems with Applications. 2023(213):118834.
8. Deng L, Deng W. Letter: Autoimmune hepatitis and metabolic syndrome-associated disease development - a US cohort study. Aliment Pharmacol Ther. 2022 Nov;56(10):1511.38.
9. He M, Chen T, Lv Y, Song P, Deng B, Guo X, Rui S, Boey J, Armstrong DG, Ma Y, Deng W. The role of allogeneic platelet-rich plasma in patients with diabetic foot ulcer: Current perspectives and future challenges. Front Bioeng Biotechnol.2022. 10:993436.37.
10. Deng L, Deng W. Association of Statin Usage and the Development of Diabetes Mellitus after Acute Pancreatitis. Clin Gastroenterol Hepatol. 2022 Aug 4:S1542-3565(22)00715-7.36.
11. Deng L, Deng W. The evolution of blue toe syndrome in a diabetic patient. Am J Med. 2022 Sep 20:S0002-9343(22)00669-6.35.
12. Rui S, Ma Y, Deng W. SLC7A11: a new regulator in diabetic wound healing. Signal Transduct Target Ther. 2022 Sep 14;7(1):320.
13. Deng L, Xie P, Chen Y, Rui S, Yang C, Deng B, Wang M, Armstrong DG, Ma Y, Deng W. Impact of acute hyperglycemic crisis episode on survival in individuals with diabetic foot ulcer using a machine learning approach. Front Endocrinol (Lausanne). 2022 Aug 25;13:974063.
14. Jiang X, Deng F, Rui S, Ma Y, Wang M, Deng B, Wang H, Du C, Chen B, Yang X, Boey J, Armstrong DG, Deng W, Duan X. The Evaluation of Gait and Balance for Patients with Early Diabetic Peripheral Neuropathy: A Cross-Sectional Study. Risk Manag Healthc Policy. 2022;15:543-552.
15. Zhang X, Wang H, Du C, Fan X, Cui L, Chen H, Deng F, Tong Q, He M, Yang M, Tan X, Li L, Liang Z, Chen Y, Chen D, Armstrong DG, Deng W. Custom-Molded Offloading Footwear Effectively Prevents Recurrence and Amputation, and Lowers Mortality Rates in High-Risk Diabetic Foot Patients: A Multicenter, Prospective Observational Study. Diabetes Metab Syndr Obes. 2022;15:103-109.
16. Du C, Li Y, Xie P, Zhang X, Deng B, Wang G, Hu Y, Wang M, Deng W, Armstrong DG, Ma Y, Deng W. The amputation and mortality of inpatients with diabetic foot ulceration in the COVID-19 pandemic and postpandemic era: A machine learning study.Int Wound J. 2022;19(6):1289-1297.
17. Xie P, Deng B, Zhang X, Li Y, Du C, Rui S, Deng W, Boey J, Armstrong DG, Ma Y, Deng W. Time in range in relation to amputation and all-cause mortality in hospitalised patients with diabetic foot ulcers. Diabetes Metab Res Rev. 2021 Sep 29:e3498.
18. Xie P, Li Y, Deng B, Du C, Rui S, Deng W, Wang M, Boey J, Armstrong DG, Ma Y, Deng W. An explainable machine learning model for predicting in-hospital amputation rate of patients with diabetic foot ulcer. Int Wound J. 2022;19(4):910-918.
19. Jiang X, Yuan Y, Ma Y, Zhong M, Du C, Boey J, Armstrong DG, Deng W, Duan X. Pain Management in People with Diabetes-Related Chronic Limb-Threatening Ischemia. J Diabetes Res. 2021;2021:6699292.
20. Rui S, Yuan Y, Du C, Song P, Chen Y, Wang H, Fan Y, Armstrong DG, Deng W, Li L. Comparison and Investigation of Exosomes Derived from Platelet-Rich Plasma Activated by Different Agonists. Cell Transplant. 2021;30:9636897211017833.
21. Du C, Wang H, Chen H, Fan X, Liu D, Du D, Wu M, Wang G, Boey J, Armstrong DG, Ma Y, Deng W. The Feasibility and Effectiveness of Wearable Sensor Technology in the Management of Elderly Diabetics with Foot Ulcer Remission: A Proof-Of-Concept Pilot Study with Six Cases.Gerontology;2021;3:1-10.
22. Deng W, Shang S , Cai X, Zhao H, Zhou Y, Chen H, Deng W. Quantum differential evolution with cooperative coevolution framework and hybrid mutation strategy for large scale optimization. Knowledge-Based Systems. 2021;224,107080.
23. Deng L, Du C, Song P, Chen T, Rui S, Armstrong DG, Deng W. The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing. Oxid Med Cell Longev. 2021;2021:8852759.
24. Shen H, Deng W, He Y, Li X, Song J, Liu R, Liu H, Yang G, Li L. Ultrasensitive aptasensor for isolation and detection of circulating tumor cells based on CeO2@Ir nanorods and DNA walker. Biosens Bioelectron. 2020;168:112516.
25. Su M, Peng J, Wu M, Deng W, Yang Y, Peng YG. Two consecutive myocardial tissue insults for inpatients with COVID-19. Crit Care. 2020;24(1):259.
26. Su M, Wang Y, Peng J, Wu MJ, Deng W, Yang YS. Elevated cardiac biomarkers are associated with increased mortality for inpatients with COVID-19: A retrospective case-control study. J Clin Anesth. 2020;65:109894.
27. Jiang X, Li N, Yuan Y, Yang C, Chen Y, Ma Y, Wang J, Du D, Boey J, Armstrong DG, Deng W. Limb Salvage and Prevention of Ulcer Recurrence in a Chronic Refractory Diabetic Foot Osteomyelitis. Diabetes Metab Syndr Obes. 2020;13:2289-2296.
28. Li A, Jiang X, Zhong M, Li N, Tao Y, Wu W, Yang C, Wang H, Min L, Ma Y, Deng W. Intractable hiccups as a rare gastrointestinal manifestation in severe endocrine and metabolic crisis: case report and review of the literature. Ther Adv Endocrinol Metab. 2020;11:2042018820934307.
29. He M, Guo X, Li T, Jiang X, Chen Y, Yuan Y, Chen B, Yang G, Fan Y, Liang Z, Armstrong DG, Deng W. Comparison of allogeneic platelet-rich plasma with autologous platelet-rich plasma for the treatment of diabetic lower extremity ulcers. Cell Transplant. 2020;29:963689720931428.
30. Chen Y, Bai W, Liu B, Huang J, Laurent I, Chen F, Deng W, Xiao X. Re-evaluation of retested nucleic acid-positive cases in recovered COVID-19 patients: Report from a designated transfer hospital in Chongqing, China. J Infect Public Health. 2020;13(7):932-934.
31. Zhang H, Deng W, Yang Y, Wei S, Xue L, Tao S. Pharmaceutic Application of Vitamin D on Particles-induced Fibrotic Effects through Induction of Nrf2 Signals. Toxicology Research.2020.2020, 1-12.
32. Ren R, Ma Y, Deng F, Li T, Wang H, Wei J, Jiang X, He M, Tian M, Liu D, Chen B, Deng W. Association between serum TSH levels and metabolic components in euthyroid subjects: a nationwide population-based study. Diabetes Metab Syndr Obes. 2019, 12:1563-1569.
33. Xie J, Li N, Jiang X, Chai L, Chen JJ, Deng W. Short-term efficacy and safety of repaglinide versus glimepiride as augmentation of metformin in treating patients with type 2 diabetes mellitus. Diabetes Metab Syndr Obes. 2019, 12:519-526.
34. Lu D, Jiang Y, Deng W (Co-first Author), Zhang Y, Liang Z, Wu Q, Jiang X, Zhang L, Gao F, Cao Y, Chen B, Xue Y. Long-Term Outcomes of BMMSC Compared with BMMNC for Treatment of Critical Limb Ischemia and Foot Ulcer in Patients with Diabetes. Cell Transplant. 2019;28(5):645-652.
35. Li T, Ma Y, Wang M, Wang T, Wei J, Ren R, He M, Wang G, Boey J, Armstrong DG, Deng W, Chen B. Platelet-rich plasma plays an antibacterial, anti inflammatory and cell proliferation promoting role in an in vitro model for diabetic infected wounds. Infection and Drug Resistance 2019:1,297-309.
36. Chen Y, Ma Y, Li N, Wang H, Chen B, Liang Z, Ren R, Lu D, Boey J, Armstrong DG,Deng W. Efficacy and long-term longitudinal follow-up of bone marrow mesenchymal cell transplantation therapy in a diabetic patient with recurrent lower limb bullosis diabeticorum. Stem Cell Res Ther. 2018. 2018;9(1):99.
37. Xie J, Deng W. Psychosocial intervention for patientsith type 2 diabetes mellitus and co-morbid depression: a meta-analysis ofrandomized controlled trials. Neuropsychiatr Dis Treat. 2017;13:2681-2690.
38. Ren Z, He M, Deng F, Chen Y, Chai L, Chen B, Deng W. Treatment of pretibial myxedema with intralesional immunomodulating therapy. Ther Clin Risk Manag. 2017;13:1189-1194.
39. Zhao J, Deng W (Co-first author), Zhang Y, Zheng Y, Zhou L, Boey J, Armstrong DG, Yang G, Liang Z, Chen B. Association between serum cystatin C and diabetic foot ulceration in patients with type 2 diabetes: A cross-sectional study. J Diabetes Res. 2016;2016:8029340.
40. Deng W, Boey J, Chen B, Byun S, Lew EJ, Liang Z, Armstrong DG. Early and Combined Use of Platelet-Rich Plasma, Bilayered Acellular Matrix Grafting, and Negative Pressure Wound Therapy in the Targeted Surgical Treatment for a Patient with Severe Necrotizing Diabetic Foot Infection. J Wound Care. 2016;25(7):393-397.
41. Deng W, Qiu S, Yang G, Chen B. Exenatide once-weekly injection for the treatment of type 2 diabetes in Chinese patients: current perspectives. Ther Clin Risk Manag. 2015;11:1153-1162.
42. Deng W, Li C, Zhang Y, Zhao J, Yang M, Tian M, Li L, Zheng Y, Chen B, Yang G.Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance.Diabetol Metab Syndr.2015;7:33.
43. Deng W, Dong X, Zhang Y, Jiang Y, Lu D, Wu Q, Liang Z, Yang G, Chen B.Transcutaneous oxygen pressure (TcPO2): a novel diagnostic tool for peripheralneuropathy in type 2 diabetes patients. Diabetes Res Clin Pract. 2014;105(3):336-43.
44. Deng W, Zhang Y, Zheng Y, Jiang Y, Wu Q, Liang Z, Yang G, Chen B. Serum retinol-binding protein 4 levels are elevated, but not with insulin resistance, in newly diagnosed Chinese hypertensive patients. Diabetol Metab Syndr. 2014,11;6:72.
(二）专利
1. 清创刮匙 ZL 201820689392.0
2. 糖尿病足防护工具箱ZL 201822274392.7
3. 高危足专用鞋垫及鞋ZL 201820689392.0
4. 创面负压吸引系统 ZL 201821318270.7
5. 糖尿病足医联体转诊系统v1.0，软著登字第9953280号
（三）项目
主持国家级项目等18项
在研科研项目：
1. 国家自然科学联合创新重点基金：下丘脑BCL6信号调节外周组织糖和能量平衡的作用机制研究
2. 重庆市科委联合重点课题：基于机器学习的高血糖危象死亡率预测及风险因素分析研究及预测系统原型研发
3. 四川省重点实验室开放基金：桑枝总生物碱对糖尿病创面血供的影响及其机制研究
4. 西部精神医学协会科研基金：不同激活剂来源的PRP-Exos对糖尿病皮肤创面的愈合作用及机制研究
5. 重庆市大数据应用发展管理局：糖尿病急慢性并发症管理系统建设与示范应用
6. 在研重庆市卫生适宜技术推广项目：急危重症内分泌代谢病的规范化诊治
已结题科研项目：
1. 国家自然科学基金：miR-21／PDCD4／NF-KB通路在血小板抗菌促糖尿病溃疡愈合中的作用及分子机制（2016.01-2019.12）
2. 国家重点研发计划专项子课题：2 型糖尿病多种危险因素综合管理的适宜技术建立与管理策略研究（2018.01-2020.12）
3. 国家卫计委卫生行业科研专项课题：糖尿病及甲状腺患病率的全国调查（2017.01-2019.12）
4. 重庆市科委社会民生科技创新专项：便携式机械动力负压创面治疗系统关键技术研究及设备开发（项目编号：cstc2016shmszx130072）
5. 重庆市卫健委医学高端人才项目：便携穿戴式加速度传感技术用于糖尿病周围神经病变的生物力学监测研究（2017.09-2019.03）
6. 重庆市科委基础研究与前沿探索专项项目：血小板来源外泌体对糖尿病创伤模型的抗菌促愈合作用及机制探索（2018.08-2021.07）
7. 重庆市卫健委医学高端人才项目：基于机器学习算法的糖尿病足复发预测模型及其应用研究（2020.11-2022.09）
8. 重庆大学中央高校医工融合项目：新型负压创面修复联合生物力学矫形技术在糖尿病足治疗和预防中的应用研究（2019.05-2021.05）
9. 重庆市科委自然科学基金面上项目：PRP-Exos 携带的TGF-β1 调控Smads／miR-21／NF-kB通路促进糖尿病创面愈合的作用及其机制（2020.07-2023.06
10. 渝中区科委课题：血小板外泌体在糖尿病创伤模型中的抗菌促愈合作用机制研究(2019.01-2020.12)
11. 重庆市教委基础研究项目：个体化运动生物力学检测联合个体化矫形鞋和鞋垫的应用对糖尿病足的预防和跌倒的多中心前瞻性对照研究（2018.09-2021.09
12. 2019年重庆市卫生适宜技术推广项目：急危重症内分泌代谢病的规范化诊治(2020.09-2021.09)
（四）著作
1. 主编《糖尿病足治疗》 (人民卫生出版社)
2. 参编《实验动物技术》(人民卫生出版社)
3. 参编《内分泌那些事》（中南大学出版社）
4. 参编《急诊医学》(全国研究生统编教材.人民卫生出版社)
5. 参编《内分泌学》 (全国规培医师统编教材.人民卫生出版社)
6. 参编《罕见病临床诊疗教程》 （人民卫生出版社）
7. 参编《糖尿病足软组织损伤》 （人民卫生出版社）
8. 参编《糖尿病足诊治病例图文精解》 （上海科技出版社）
9. 参译《糖尿病足综合症》 (天津翻译出版社)
10. 参编《消化内分泌学》 (人民卫生出版社)
11. 参译《糖尿病足》 (人民卫生出版社)
12. 《内分泌学高级教程》 (高级职称统编教材.人民卫生出版社).
（五）获奖
1. 2012年军队医疗成果二等奖
2. 2015年美国亚利桑那大学KEYS Summer Intern Program奖
3. 2021年、2022年国家卫健委“好医生”提名
4. 第五、七、九届树兰医学”青年奖提名
5. 2019年重庆市卫生健康系统“先进个人”
6. “白求恩式好医生”提名奖
7. 重庆市第八届“重庆名医”
